(2020/10) Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials.
(2018/10) CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity.
(2018/03) Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial.
(2017/05) The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques.
(2015/10) Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.
(2014/06) Coenzyme Q10 Supplementation and Oocyte Aneuploidy in Women Undergoing IVF-ICSI Treatment.
(2013/01) The aging oocyte--can mitochondrial function be improved?
(2012/04) Coenzyme Q10 content in follicular fluid and its relationship with oocyte fertilization and embryo grading
Fertility Scientific References
Fertility | Chronic Pain Support | General Health | Immune Support | Plant Based Nutrition | Rheumatology | Sports Nutrition | Urology | Women's Health
LATEST RESEARCH UPDATE: A systematic review and meta-analysis found that vitamin D supplementation significantly increased clinical pregnancy rate among infertile women. Compared to control, pooled results showed: vitamin D increased clinical pregnancy rate by 70%. Further analysis found that vitamin D supplementation significantly increased pregnancy rate when: Baseline 25(OH)D level was <30ng/mL; Daily dose was 1,000-10,000 IU (25-250 mcg); Supplement duration was >30 days. Check out the full abstract here.
Female Fertility
(2021/07) Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age.
(2020/09) Dehydroepiandrosterone supplementation improves ovarian reserve and pregnancy rates in poor responders.
(2020/08) Ovarian stimulation after dehydroepiandrosterone supplementation in poor ovarian reserve: a randomized clinical trial.
(2019/03) Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women.
(2018/11) DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve: A systematic review and meta-analysis.
(2018/09) Dehydroepiandrosterone (DHEA) supplementation improves in vitro fertilization outcomes of poor ovarian responders, especially in women with low serum concentration of DHEA-S: a retrospective cohort study.
(2017/12) Dehydroepiandrosterone as a potential agent to slow down ovarian aging.
(2017/05) The effect of dehydroepiandrosterone supplementation on ovarian response is associated with androgen receptor in diminished ovarian reserve women.
(2017/04) Evaluation of Dehydroepiandrosterone Supplementation on Diminished Ovarian Reserve: A Randomized, Double-Blinded, Placebo-Controlled Study.
(2016/07) Effect of dehydroepiandrosterone administration in Chinese women over 37 years undergoing assisted reproductive techniques.
(2016/05) The effect of dehydroepiandrosterone (DHEA) supplementation on women with diminished ovarian reserve (DOR) in IVF cycle: Evidence from a meta-analysis.
(2015/12) A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection.
(2015/03) Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old.
(2015/02) Potential benefit of dehydroepiandrosterone supplementation for infertile but not poor responder patients in a IVF program.
(2014/07) A randomized, controlled, pilot trial on the effect of dehydroepiandrosterone on ovarian response markers, ovarian response, and in vitro fertilization outcomes in poor responders.
(2014/06) Effect of dehydroepiandrosterone administration in patients with poor ovarian response according to the Bologna criteria.
(2014/06) Role of dehydroepiandrosterone in improving oocyte and embryo quality in IVF cycles.
(2014/02) Does dehydroepiandrosterone supplementation really affect IVF-ICSI outcome in women with poor ovarian reserve?
(2014/01) DHEA pre-treated patients, poor responders to a first IVF (ICSI) cycle: clinical results.
(2013/11) A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve.
(2013/10) DHEA supplementation positively affects spontaneous pregnancies in women with diminished ovarian function.
(2013/07) Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count.
(2013/05) DHEA supplementation may improve IVF outcome in poor responders: a proposed mechanism.
(2013/01) Starting and resulting testosterone levels after androgen supplementation determine at all ages in vitro fertilization(IVF) pregnancy rates in women with diminished ovarian reserve (DOR).
(2012/09) DHEA supplementation improves follicular microenviroment in poor responder patients.
(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.
(2010/11) Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: direct evidence from preimplantation genetic screening (PGS).
(2010/10) Addition of dehydroepiandrosterone (DHEA) for poor-responder patients before and during IVF treatment improves the pregnancy rate: a randomized prospective study.
(2000/10) Dehydroepiandrosterone supplementation augments ovarian stimulation in poor responders: a case series.
(2022/11) Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts.
(2022/10) Folic acid versus 5- methyl tetrahydrofolate supplementation in pregnancy.
(2022/09) Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate.
(2021/09) Comparative Study between the Use of Regular Folic Acid Supplement versus the Use of L-Methyl Folate in Patients with Methyl Tetrahydrofolate Reductase (MTHFR) Gene Mutation with Recurrent Pregnancy Loss.
(2018/08) MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.
(2017/12) Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects.
(2016/12) Effects of folic acid supplementation during different pregnancy periods and relationship with the other primary prevention measures to neural tube defects.
(2015/12) Effects and safety of periconceptional oral folate supplementation for preventing birth defects.
(2015/01) Folic acid supplementation and dietary folate intake, and risk of preeclampsia.
(2013/09) Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?
(2006/07) Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age.
(2023/01) Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
(2021/09) Myoinositol versus metformin pretreatment in GnRH-antagonist cycle for women with PCOS undergoing IVF: a double-blinded randomized controlled study.
(2020/09) Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trial.
(2019/01) Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial.
(2018/12) Inositol for subfertile women with polycystic ovary syndrome.
(2018/10) Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials.
(2018/02) Inositol treatment of anovulation in women with polycystic ovary syndrome: a meta-analysis of randomised trials.
(2017/12) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET.
(2017/07) Myo-inositol administration positively effects ovulation induction and intrauterine insemination in patients with polycystic ovary syndrome: a prospective, controlled, randomized trial.
(2016/10) Inositol Treatment and ART Outcomes in Women with PCOS.
(2016/08) Prospective Randomized Study on the Influence of Myoinositol in PCOS Women Undergoing IVF in the Improvement of Oocyte Quality, Fertilization Rate, and Embryo Quality
(2015/08) Inositol versus Metformin administration in polycystic ovary syndrome patients: a case–control study
(2015/06) Myo-inositol therapy for poor-responders during IVF: a prospective controlled observational trial
(2015/02) Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance
(2013/12) The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial
(2013/04) Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome. A randomized study.
(2012/07) Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study.
(2011/05) Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double-blind trial.
(2011/04) Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.
(2010/04) Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women.
(2009/05) Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial.
(2007/09) Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.
(2018/02) Melatonin Treatment May Be Able to Restore Menstrual Cyclicity in Women With PCOS: A Pilot Study.
(2017/12) The impact of melatonin on the sleep patterns of women undergoing IVF: a double blind RCT.
(2017/04) Melatonin levels in follicular fluid as markers for IVF outcomes and predicting ovarian reserve.
(2016/01) Effect of myo-inositol and melatonin versus myo-inositol, in a randomized controlled trial, for improving in vitro fertilization of patients with polycystic ovarian syndrome.
(2014/10) Melatonin: shedding light on infertility? - a review of the recent literature.
(2014/05) Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer.
(2014/01) Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology: systematic review and meta-analysis of randomized controlled trials.
(2012/02) The efficacy of melatonin administration on oocyte quality.
(2011/11) Effect of a supplementation with myo-inositol plus melatonin on oocyte quality in women who failed to conceive in previous in vitro fertilization cycles for poor oocyte quality: a prospective, longitudinal, cohort study.
(2011/09) Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances, but does not improve the sleeping problems.
(2010/06) Effect of the treatment with myo-inositol plus folic acid plus melatonin in comparison with a treatment with myo-inositol plus folic acid on oocyte quality and pregnancy outcome in IVF cycles. A prospective, clinical trial.
(2008/04) Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate.
(2022/08) Omega-3 fatty acids dietary intake for oocyte quality in women undergoing assisted reproductive techniques: A systematic review.
(2019/08) Reduction in FSH Throughout the Menstrual Cycle After Omega-3 Fatty Acid Supplementation in Young Normal Weight but not Obese Women.
(2018/01) Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction.
(2017/12) The association between fatty acid index and in vitro fertilization outcomes.
(2017/11) Omega-3 fatty acid supplementation significantly lowers FSH in young normal weight women.
(2012/11) Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids.
(2011/04) Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology.
(2010/09) The effect of supplementation with omega-3-polyunsaturated fatty acids in intracytoplasmic sperm injection cycles for infertile patients with a history of unexplained total fertilization failure.
(2023/02) Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: a systematic review and meta-analysis.
(2022/06) Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: a systematic review and meta-analysis.
(2022/02) The Effects of Follicular Fluid 25(OH)D Concentration on Intrafollicular Estradiol Level, Oocyte Quality, and Fertilization Rate in Women Who Underwent IVF Program.
(2020/06) Normal fertilisation rates and serum 25-OHD levels among couples undergoing in-vitro fertilisation: a prospective cohort study.
(2018/05) Association of preconception serum 25-hydroxyvitamin D concentrations with livebirth and pregnancy loss: a prospective cohort study.
(2018/01) Vitamin D and assisted reproductive treatment outcome: a systematic review and meta-analysis.
(2014/11) Vitamin D deficiency and infertility: insights from in vitro fertilization cycles.
(2014/09) Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ICSI.
(2014/07) Association Between Sex Steroids, Ovarian Reserve, and Vitamin D Levels in Healthy Nonobese Women
(2014/04) Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization
(2014/02) Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles.
(2013/06) Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization.
(2012/11) Characterizing the influence of vitamin D levels on IVF outcomes.
(2011/08) Predictive value of the level of vitamin D in follicular fluid on the outcome of assisted reproductive technology
(2010/09) Replete vitamin D stores predict reproductive success following in vitro fertilization.
(2010/07) Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome
Male Fertility
(2023/03) Effectiveness of Nutritional Therapies in Male Factor Infertility Treatment: A Systematic Review and Network Meta-analysis.
(2023/03) Antioxidant Supplementation on Male Fertility—A Systematic Review .
(2022/07) Improvement in sperm quality by oral antioxidant supplementation in infertile men with varicocele who have not undergone surgical repair: Systematic review and meta-analysis.
(2018/01) Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate.
(2016/12) Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters.
(2015/09) Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
(2013/06) Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA.
(2012/11) Micronutrients intake is associated with improved sperm DNA quality in older men.
(2021/06) Coenzyme Q10, oxidative stress markers, and sperm DNA damage in men with idiopathic oligoasthenoteratospermia.
(2021/04) Coenzyme Q10 Improves Sperm Parameters, Oxidative Stress Markers and Sperm DNA Fragmentation in Infertile Patients with Idiopathic Oligoasthenozoospermia.
(2021/02) The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, before and after Freezing in Oligospermia Men.
(2014/03) Effect of Coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial.
(2012/08) Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study
(2011/09) Coenzyme Q(10) in male infertility: physiopathology and therapy
(2011/09) Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial.
(2009/07) Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men.
(2009/05) Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial.
(2018/08) MTHFR isoform carriers. 5-MTHF (5-methyl tetrahydrofolate) vs folic acid: a key to pregnancy outcome: a case series.
(2009/08) Low folate in seminal plasma is associated with increased sperm DNA damage
(2008/05) The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.
(2002/03) Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial.
(2001/02) Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers.
(2019/11)The effect of Myo-inositol on sperm parameters and pregnancy rate in oligoasthenospermic men treated with IUI: A randomized clinical trial.
(2019/10) Myo-inositol in health and disease: its impact on semen parameters and male fertility.
(2017/06) Myo-inositol as a male fertility molecule: speed them up!
(2015/04) Myoinositol improves sperm parameters and serum reproductive hormones in patients with idiopathic infertility: a prospective double-blind randomized placebo-controlled study.
(2023/03) Effectiveness of Nutritional Therapies in Male Factor Infertility Treatment: A Systematic Review and Network Meta-analysis.
(2021/02) The Effect of L-Carnitine and Coenzyme Q10 on the Sperm Motility, DNA Fragmentation, Chromatin Structure and Oxygen Free Radicals During, before and after Freezing in Oligospermia Men.
(2015/09) Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.
(2015/09) Efficacy of tamoxifen and l-carnitine on sperm ultrastructure and seminal oxidative stress in patients with idiopathic oligoasthenoteratozoospermia.
(2015/06) Protective effects of l-carnitine on astheno- and normozoospermic human semen samples during cryopreservation.
(2015/01) Effect and safety of L-carnitine in the treatment of idiopathic oligoasthenozoospermia: a systemic review.
(2010/06) Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study.
(2007/12) Effect of L-carnitine and/or L-acetyl-carnitine in nutrition treatment for male infertility: a systematic review.
(2006/05) Carnitine for the treatment of idiopathic asthenospermia: a randomized, double-blind, placebo-controlled trial.
(2005/12) The effects of L-carnitine on sperm parameters in smoker and non-smoker patients with idiopathic sperm abnormalities.
(2005/09) Placebo-controlled double-blind randomized trial on the use of L-carnitine, L-acetylcarnitine, or combined L-carnitine and L-acetylcarnitine in men with idiopathic asthenozoospermia.
(2003/02) Use of carnitine therapy in selected cases of male factor infertility: a double-blind crossover trial.
(2016/12) Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation.
(2016/04) Association of decreased spermatozoa omega-3 fatty acid levels and increased oxidative DNA damage with varicocele in infertile men: a case control study.
(2015/05) Dietary fatty acids affect semen quality: a review.
(2012/05) Dietary fat and semen quality among men attending a fertility clinic.
(2010/02) Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: a comparison between fertile and infertile men.
(2011/01) Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate
(2009/02) Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study
(2003/03) Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
(1998/07) The effect of oral selenium supplementation on human sperm motility.
(2022/01) Relationship between serum vitamin D levels semen parameters and sperm DNA damage in men with unexplained infertility.
(2015/11) Males with low serum levels of vitamin D have lower pregnancy rates when ovulation induction and timed intercourse are used as a treatment for infertile couples: results from a pilot study.
(2012/05) Vitamin D and fertility: a systematic review.
(2011/06) Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa.
(2011/01) Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate
(2010/05) Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial
(2003/03) Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men.
(1996/09) Lipid peroxidation and human sperm motility: protective role of vitamin E.
(1996/09) The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program.
(1995/10) A double-blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility.
(2008/05) The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men.
(2002/03) Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial
(2000/01) Comparison of zinc concentrations in blood and seminal plasma and the various sperm parameters between fertile and infertile men.
(1999/03) Relationship between zinc concentrations in seminal plasma and various sperm parameters.
(1998/01) Changes in seminal quality following oral zinc therapy.
