General Health Scientific References

Fertility | Chronic Pain Support | General Health | Immune Support | Plant Based Nutrition | Rheumatology | Sports Nutrition | Urology | Women's Health


LATEST RESEARCH UPDATE: A recently published meta-analysis found that daily omega-3 fish oil supplementation significantly decreased blood pressure levels. This dose-response meta-analysis of 71 clinical trials and nearly 5000 people, published in the Journal of the American Heart Association, found that those who took 2-3 grams per day (g/d) of EPA+DHA omega-3 fish oil supplements for 10 weeks had a statistically significant decrease in blood pressure. Results showed a significant nonlinear dose-response relationship for both systolic and diastolic blood pressure, with dosages of 2-3 g/d associated with the most significant reduction relative to the reference dose (0 g/d). Doses over 3 g were associated with weaker or null changes. For more information check out the full study.


Bone Health

Combination of Calcium and Vitamin D
Vitamin D
Vitamin K

(2012/01) Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials.

(2011/11) Intake of vitamin K1 and K2 and risk of hip fractures: The Hordaland Health Study.

(2011/06) Dietary vitamin K intake is associated with bone quantitative ultrasound measurements but not with bone peripheral biochemical markers in elderly men and women.

(2011/06) Vitamin K: fracture prevention and beyond.

(2009/06) Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.

(2008/10) Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial.

(2008/05) Vitamin K1 intake is associated with higher bone mineral density and reduced bone resorption in early postmenopausal Scottish women: no evidence of gene-nutrient interaction with apolipoprotein E polymorphisms.

(2008/04) Effect of vitamin K supplementation on bone loss in elderly men and women.

(2007/04) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women.

(2006/06) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.

(2003/07) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age.

(2000/05) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women.


Cognitive Health

Palmitoylethanolamide (PEA)






Vitamin C


Heart Health

Coenzyme Q10

(2019/02) Effect of coenzyme Q10 in Europeans with chronic heart failure: A sub-group analysis of the Q-SYMBIO randomized double-blind trial.

(2018/09) Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials.

(2012/12) A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the metabolic syndrome.

(2012/11) Impact of coenzyme Q-10 on parameters of cardiorespiratory fitness and muscle performance in older athletes taking statins

(2012/11) The effect of coenzyme Q10 in statin myopathy.

(2012/08) Effect of coenzyme Q10 supplementation on statin-induced myalgias

(2012/02) Strategies to preserve the use of statins in patients with previous muscular adverse effects

(2010/07) Coenzyme Q10: a therapy for hypertension and statin-induced myalgia?

(2009/10) Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.

(2007/06) The role of coenzyme Q10 in statin-associated myopathy: a systematic review.

(2007/05) Effect of coenzyme q10 on myopathic symptoms in patients treated with statins

(2005/11) Muscle coenzyme Q10 level in statin-related myopathy.

(2004/05) Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study.

(2003/01) Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.

(1999/05) Lack of effect of coenzyme Q on left ventricular function in patients with congestive heart failure.

(1999/03) Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease.

(1995/03) Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 Study Group.

(1994/12) Coenzyme Q10 in essential hypertension.

(1994/12) Treatment of essential hypertension with coenzyme Q10.

(1994/12) Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators.

(1993/12) Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study.

Omega-3 Fish Oil

(2023/09) Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease: A Novel Analysis of the VITAL Trial Using Win Ratio and Hierarchical Composite Outcomes.

(2023/07) Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation.

(2023/05) Does omega-3 PUFAs supplementation improve metabolic syndrome and related cardiovascular diseases? A systematic review and meta-analysis of randomized controlled trials.

(2022/06) Omega‐3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials.

(2014/07) Long-Chain Omega-3 Fatty Acids Eicosapentaenoic Acid and Docosahexaenoic Acid and Blood Pressure: A Meta-Analysis of Randomized Controlled Trials.

(2011/11) Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events.

(2011/10) Impact of low vs. moderate intakes of long-chain n-3 fatty acids on risk of coronary heart disease.

(2010/03) Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides

(2010/01) Fish oil for primary and secondary prevention of coronary heart disease.

(2008/07) Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: subanalysis of the JELIS trial.

(2006/12) The triglyceride-lowering effects of a modest dose of docosahexaenoic acid alone versus in combination with low dose eicosapentaenoic acid in patients with coronary artery disease and elevated triglycerides.

(2006/08) Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids.

(2006/08) Secondary prevention of coronary artery disease with omega-3 fatty acids.

(2006/08) Combination Therapy with Statins and Omega-3 Fatty Acids

(2006/08) Dietary omega-3 fatty acid intake and cardiovascular risk.

(2006/03) The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans.

(2002/11) Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

(1999/08) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.

Vitamin D


Immune Function

Cannabidiol (CBD)
Green Tea
Palmitoylethanolamide (PEA)
Vitamin C
Vitamin D


Joint Health

Glucosamine and Chondroitin
Palmitate Monoethanolamide (PEA)
Vitamin D


Plant Based Nutrition



Sleep Health

Cannabidiol (CBD)
Omega-3 Fatty Acids
Palmitate Monoethanolamide (PEA)


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